Sede donde se gestiona
Lugar de impartición
Valencia (Palau de Pineda - Plaza del Carmen, 4)
DirecciónAntonio Marcilla DíazUniversitat de València
SecretaríaMaría Yáñez MóUniversidad Autónoma de Madrid, Centro de Biología
Molecular Severo Ochoa, Madrid
Descripción de la actividad
1) Provide students, clinicians, academics and researchers with updated knowledge on extracellular vesicles.
2) Analyze the role of extracellular vesicles in health and disease as well as their applications in biomedicine.
3) Encourage interactions among researchers and clinicians.
-Graduate students (Master Thesis and PhD students).
-Lecturers and senior researchers.
-Clinicians and health workers (Medical doctors; surgeons; Physicians; Nurses; Technicians).
Cells secrete continuously membrane vesicles to the extracellular space. These extracellular vesicles (EVs) are called exosomes, microvesicles and apoptotic bodies based on their origin and size. EV protein composition is characteristic, and due to their typical surface proteins, they can be recognized by different acceptor cells, uptaken and release their content into the target cell. Thus, EVs have been proposed as mediators of cell-to-cell communication in multiple biological and pathological processes such as coagulation, angiogenesis and tumor progression. EVs are involved in the generation and modulation of the immune response, and have been also implicated in the transmission of pathogens.
The fact that EVs can be detected in many biological fluids, including blood, saliva, urine and milk, and their genetic content analyzed, makes them great candidates as non-invasive biomarkers for the diagnosis of different pathological processes such as chronic inflammation, cancer, cardiovascular diseases or infectious diseases.
In this course we intend to bring the study of extracellular vesicles to the audience, making them familiar with their purification procedures, composition and characterization. We also will discuss their clinical applications in diagnosis and monitoring of diseases, their usefulness as vehicles for specific and selective treatments, as well as for vaccination.
Acreditada por la Comisión de Formación Continuada: 4,1 créditos
Reconocida como actividad de interés sanitario por la Conselleria de Sanitat